
The framework contains three phases: the Define phase, which aims to define and characterise the disaster risk management context and end-user group who will benefit from a visualisation the Design phase, which is highly iterative and presents an opportunity to test how users interpret different design elements and the Refine phase, which focuses on evaluating how users understand, respond to, and make decisions based on the visualisation. To address this, we present a unifying user-centred design framework for disaster risk visualisation, based on existing visualisation frameworks. We find that, despite being widely recommended, tailoring visualisations to users through the process of user-centred design remains a relatively unexplored topic within disaster risk. We conducted a systematic literature review to understand the current state developing disaster risk visualisations following design best practices and accounting for the heterogeneity between end-users and disaster risk contexts. However, the diversity of risk management contexts and user characteristics is a challenge to develop understandable and useable visualisations. Visualisations are powerful communication tools that have the potential to help societies assess and manage natural hazard and disaster risks.

Based on these findings we propose a theory of how both general and individual development of drawing could be explained in a unified manner within the framework of predictive coding. Furthermore, individual differences that are prevalent in children's drawings, might arise from different developmental pathways regarding the precision of these two signals. This comparison revealed that a gradual increase in children's precision of top-down and bottom-up information as they develop effectively explains the observed change of drawing style from scribbling toward representational drawing. We compared the drawings produced by our model to a dataset of drawings created by children aged between 2 and 8 years old who drew on incomplete drawings. The results indicated that sufficient precision of both signals was required for the successful completion of the stimuli and that a reduced precision in either sensory or prediction (i.e., prior) information led to different types of atypical drawing behavior. In this study, we used a computational model of drawing based on the mechanisms of predictive coding to systematically investigate the effects of the precision of top-down and bottom-up information when performing a drawing completion task. However, the gap between the computational accounts of cognition and evidence of behavioral studies remains large. Predictive coding has recently been proposed as a mechanistic approach to explain human perception and behavior based on the integration of perceptual stimuli (bottom-up information) and the predictions about the world based on previous experience (top-down information). The model therefore offers fundamental theoretical insights into the effective system control of the HPT axis. Simultaneously, the model accounts for the combination of properties regarded as essential to endocrine regulation, namely sensitivity, the anticipation of an adverse event, robustness, and adaptation. Preservation of FT3 homeostasis, despite changes in FT4 and TSH levels, is found to be an achievable system goal by joining elements of top-down and bottom-up regulation in a cascade of targeted feedforward and feedback loops.

Together these allow optimum resilience in stressful situations. One mechanism supports the preservation of FT3 homeostasis, whilst the other is responsible for the adaptation of the homeostatic state to a new level.
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In particular, it allows uncovering mechanisms for the homeostasis of the key biologically active hormone free triiodothyronine (FT3). A new minimal mathematical model, in the form of a parametrized nonlinear dynamical system, is here formulated as a proof-of-concept to elucidate the principles of the HPT axis regulation. Under certain conditions, such flexibility may exceed the capability of a simple feedback control loop, rather requiring more intricate networks of communication between the system’s components. Essentially, it provides either of the two responses to overt biological challenges: to defend the homeostatic range of a target hormone or adapt it to changing environmental conditions.

Endocrine regulation in the hypothalamic-pituitary-thyroid (HPT) axis is orchestrated by physiological circuits which integrate multiple internal and external influences.
